After three years of intense training under four notorious masters in prison, Serena Rivers emerges as the feared Dark Prison's Female Shura, mastering medicine, poison, bloodline power, and control over men. She has been hunting Xavier Stone, the strongest warden of the 9,800th Prison, to use his Frost Poison to suppress her Vermilion bloodline and enhance her strength. With his help, she plans to settle a past score with the Rivers family. As her term ends, Serena returns to the Stone family, revealing her intent to marry the Rivers eldest daughter, setting the stage for a new deadly game between Serena and her future rival.